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More HLA, more than HLA

The next-generation in genetic matching.

  • Expandable gene content without affecting lab workflow
  • Easy single tube workflow with early indexing step
  • No long-range PCR = no amplification inefficiencies
  • Fast software analysis with data upload at 1 min/sample

The cutting edge solution to detect donor-derived cell-free DNA

AlloSeq cfDNA is a kit based solution that enables measurement of dd-cfDNA through a blood test.

  • A minimally invasive blood test that measures dd-cfDNA
  • A kit based test to run in your own lab and does not require prior genotyping
  • A simple workflow that provides sample to report solution within 24 hours
  • AlloSeq Tx 17
  • QTYPE
  • TruSight HLA

More HLA, more than HLA

The next-generation in genetic matching.

AlloSeq Tx 17 offers a single tube workflow and no long-range PCR inefficiencies.

What is AlloSeq Tx 17?

AlloSeq Tx 17 helps you to identify the best genetic match by using innovative hybrid capture NGS technology. 

AlloSeq Tx 17 moves beyond the traditional transplant related loci to consider more transplant associated genes.  As we continue to improve our understanding of the “Transplantome™”, additional targets can be added to the AlloSeq Tx 17 assay without impacting workflows or laboratory procedures.

GENE RESOLUTION COVERAGE
HLA-A 4th field Full Gene
HLA-B 4th field Full Gene
HLA-C 4th field Full Gene
HLA-E 4th field Full Gene
HLA-F 4th field Full Gene
HLA-G 4th field Full Gene
HLA-H 4th field Full Gene
DRB1 3rd field Full Exon
DRB3/4/5 3rd field Full Exon
DQA1 3rd field Full Exon
DQB1 3rd field Full Exon
DPA1 3rd field Full Exon
DPB1 3rd field Full Exon
MICA 2nd field Full Exon
MICB 2nd field Full Exon

AlloSeq Tx 17 offers a single tube workflow

Step 1 - Whole genome library generation
Step 2 - Hybrid capture

QTYPE - HLA typing in real time

QTYPE® enables speed and precision in HLA typing at a low to intermediate resolution for samples that require a fast turn-around-time. The QTYPE real time system consists of the QTYPE HLA typing kit and the SCORE 6 interpretation software.

  • Rapid and accurate HLA typing
  • Straightforward analysis
  • Primer/probe technology increases capacity for future expansion

TruSight HLA

TruSight® HLA v2 Sequencing Panel provides clinical researchers with a broad-coverage, high–resolution human leukocyte antigen (HLA) typing solution for simple, rapid assessment of the HLA region in a single assay.

Interested in the next-generation in genetic matching that offers a single tube workflow and no long-range PCR inefficiencies?

  • AlloSeq cfDNA
  • AlloSeq HCT

The cutting edge solution to detect donor-derived cell-free DNA

AlloSeq cfDNA is a kit based solution that enables measurement of dd-cfDNA through a blood test.

What is AlloSeq cfDNA?

  • A minimally invasive blood test that measures dd-cfDNA
  • A kit based test to run in your own lab and does not require prior genotyping
  • A simple workflow that provides sample to report solution within 24 hours

What is cell-free DNA (cfDNA)?

  • Cell-free DNA refers to fragments of DNA in the bloodstream that originate from cells undergoing cell injury and death
  • DNA degrades into nucleosomal units consisting of ~166 bases
  • Cell-free DNA is cleared from the blood by the liver and kidney and has a half-life of about 30 minutes

AlloSeq cfDNA = AlloSure, and it is validated

  • AlloSure dd-cfdna is validated in a 14 center prospective study
  • Broadly used in over 150 transplant centers
  • Used in re-transplants

Revolutionizing chimerism monitoring

The latest innovation in chimerism testing offers streamlined workflow with best-in-class sensitivity.

Chimerism changes post stem-cell transplant can be an early indication of relapse. *Early detection can lead to early intervention.

What is AlloSeq HCT?​

  • A NGS-based chimerism testing solution that is able to determine the relative contribution of up to 3 genomes i.e. up to two donors per recipient
  • A kit-based test that offers high quality data with a recommended input of 10 ng of gDNA and up to 24 samples per batch
  • A one-step multiplex assay that utilizes 202 SNPs across all autosomal chromosomes to differentiate between recipient and donor(s) gDNA
  • A highly sensitive assay with a scalable and timesaving software solution with automated analysis

AlloSeq HCT is a simple and fast assay with minimal hands-on time.

AlloSeq HCT provides easy and fast analysis with automated results.

The Software is LIMS compatible with an user friendly interface and can be used with any Windows computer. All samples will be reported on a single screen.

Additional CareDx lab products

Find out about our Olerup SSP®, Olerup SBT, and Olerup XM-ONE® products .

Webinars

Posters and Presentations

  • EFI 2020 4th Field Resolution Typing is Critical for Defining the MHC Haplotype Structure Between HLA-F and HLA-E: Implications for Matching in HSCT. View presentation.
  • EFI 2020 Laboratory Validation of CE-marked AlloSeq cfDNA to Measure Donor-derived Cell-free DNA in Transplant Patients. View poster.
  • EFI 2020 Kidney Transplantation Beyond HLA APOL1 Testing by qPCR. View poster.
  • EFI 2020 AlloSeq Tx Genotyping Using DNA Extracted from Saliva. View poster.
  • EFI 2020 Accurate, Reproducible and Sensitive Chimerism Monitoring with NGS-based AlloSeq HCT. View poster.
  • EFI 2020 HLA typing with QTYPE 11 using DNA extracted from saliva. View poster.
  • TCT 2020 AlloSeq HCT: A Wide Range Chimerism Testing Solution with High Sensitivity, Accuracy and Precision for Routine Post Hematopoietic Cell Transplant Monitoring. View poster.
  • EFI 2019 AlloSeq cfDNA, a Donor-Derived Cell-Free DNA measurement solution for on-site monitoring of Solid Organ Transplants. View poster.
  • EFI 2019 QTYPE, the Fastest Method for HLA Genotyping by Real-Time PCR. View poster.

Videos

Poster Videos
Laboratory Validation of CE-marked AlloSeq cfDNA to Measure Donor-derived Cell-free DNA in Transplant Patients
Kidney Transplantation Beyond HLA APOL1 Testing by qPCR
AlloSeq Tx Genotyping Using DNA Extracted from Saliva
Accurate, Reproducible and Sensitive Chimerism Monitoring with NGS-based AlloSeq HCT
4th Field Resolution Typing is Critical for Defining the MHC Haplotype Structure Between HLA-F and HLA-E: Implications for Matching in HSCT
HLA Typing with QTYPE 11 Using DNA Extracted from Saliva
QTYPE Videos
Introducing Olerup QTYPE
Olerup QTYPE and SCORE 6

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