ImmuneScape™
Illuminating the Biology Behind Transplant Health
ImmuneScape is a CareDx research initiative designed to explore the intricate immune ecosystems present in transplanted organs. Using cutting‑edge single‑cell and spatial transcriptomic approaches, in collaboration with 10x Genomics, the program aims to generate high‑resolution views of the cellular activity that shapes graft outcomes that may support future innovations in both diagnostic research and therapeutic exploration.
Revealing Complexity, Not Just Signals
Transplant biology is shaped by diverse immune cells, dynamic micro‑environments, and interactions that unfold deep within tissue architecture. ImmuneScape, utilizing the 10x Chromium Flex and Xenium platforms, seeks to illuminate these processes at unprecedented resolution, helping researchers explore:
Cellular neighborhoods and tissue structures within transplanted organs
Immune‑cell pathways and signatures that may be associated with conditions such as antibody‑mediated rejection (AMR) and microvascular inflammation (MVI)
Biological features that researchers may consider relevant when studying response to therapies, including targeted agents such as anti‑CD38
High-Resolution Insights
ImmuneScape leverages state‑of‑the‑art spatial and single‑cell technologies to:
Visualize immune cell neighborhoods within transplant tissue
Characterize immune activity as it occurs in situ
Explore tissue‑level biology that shapes graft health and therapeutic response
These exploratory datasets are intended to deepen scientific understanding and support future research into transplant diagnostics through complementary layers of biology, pairing spatial context with cellular granularity to generate rich, multi‑dimensional tissue profiles.
Advancing Precision Transplant Research
ImmuneScape builds on CareDx’s broader commitment to multiomic innovation for precision organ health, including products such as HistoMap™ Kidney, a tissue‑based gene‑expression classifier for studying rejection subtypes. By generating comprehensive biological insights, the program is intended to support ongoing scientific efforts that may inform next‑generation approaches in transplant care—particularly where therapy selection, immune modulation, and disease‑driven biology intersect.
CareDx is collaborating with multiple academic institutions on ImmuneScape™, reflecting our sustained scientific leadership and shared commitment to advancing transplant research.
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