Know More, Sooner: HeartCare
Learn how HeartCare works, what your results may mean, and how CareDx supports heart transplant recipients with specialized monitoring, patient resources, and dedicated care team access.
Medically reviewed by Dr. Jeremy Kobulnik, MD, MHSc
Last updated: September 8, 2026
Medically reviewed by Dr. Jeremy Kobulnik, MD, MHSc
Last updated: September 8, 2026
What is HeartCare?
HeartCare combines two blood tests—AlloMap Heart and AlloSure Heart—that give your transplant team a clearer, more complete picture of your heart’s health. Used together, they can detect early signs of injury or rejection sooner than either test alone—and may reduce the need for invasive biopsy.1
How it works
AlloMap Heart and AlloSure Heart each measure something different:
AlloMap Heart measures the activity of genes involved in your immune system. If those genes are active in a way that suggests your immune system is reacting, it can be an early signal of possible rejection.
AlloSure Heart measures how much DNA from your transplanted heart is in your bloodstream—called donor-derived cell-free DNA (dd-cfDNA). If your heart is experiencing active injury, it releases more of its DNA into the bloodstream.
Together, these two tests give your care team a fuller picture of your heart’s health than either test alone.
Accessing and understanding your HeartCare results
How do I access my results?
You can access your HeartCare results through the CareDx patient portal. Your results are also shared directly with your transplant care team.
Your transplant team may review your HeartCare results alongside routine lab work, symptoms, imaging, and other monitoring information to help understand the health of your transplanted heart over time.
What do my results mean?
By looking at both AlloSure and AlloMap, your care team gets a fuller view of your heart’s health and what it may need next.
If both scores are negative: You have a lower risk of injury or rejection.1,3
If one score is positive, one negative: This may be an early sign that something could be wrong with your heart. The result allows your doctor to take action to learn more.1
If both scores are positive: You have a higher risk of injury or rejection. Early action may help protect your heart.1,3
Talk with your transplant doctor or transplant coordinator if you have any questions about your HeartCare results.
Questions you may want to ask your care team
What can HeartCare tell you that routine labs or biopsy alone cannot?
How would HeartCare fit into my post-transplant monitoring plan?
How often would I get AlloMap and AlloSure tests?
Getting your HeartCare blood test
HeartCare is a simple, non-invasive blood test that fits easily into your routine transplant care.
Your doctor orders the test
Your transplant team will prescribe HeartCare as part of your monitoring plan.
Your blood draw
A trained phlebotomist draws a small blood sample—usually at a lab, your transplant center, or another convenient location close to you.
Your sample is processed
Your blood sample is sent to a CareDx laboratory, where it is analyzed.
Results go to your doctor
Your HeartCare results are sent directly to your transplant care team, who will review them with you.
Interested in getting your blood draw done at home?
Ask your doctor about mobile phlebotomy. If your transplant center participates in CareDx’s at-home testing program, the CareDx Care Team can help coordinate a licensed mobile technician to come to your home—at no additional cost to you.
Contact our expert Care Team for personalized support whenever you need it:
1-888-255-6627
Monday to Friday, 6:00 AM to 5:00 PM (Pacific Time)
Customer Care Fax: 415-287-2456
E-mail: customercare@caredx.com
Transplant-focused care
For more than 25 years, CareDx has focused on transplant care. We support transplant patients with specialized monitoring tools, patient support services, specialized pharmacy services, and educational resources designed specifically for the transplant journey.
This deep focus helps us understand the challenges that can come before, during, and long after transplant. Our goal is to help transplant recipients and their care teams feel more informed and confident throughout the journey.
Your transplant journey is ongoing, and monitoring is an important part of protecting the health of your transplanted heart over time.
Commonly asked questions
AlloSure is covered by Medicare when coverage criteria are met. Commercial coverage varies. CareDx can help you understand your insurance coverage, billing, and financial support options.
Khush K, Hall S, Kao A, et al. Surveillance with dual noninvasive testing for acute cellular rejection after heart transplantation: outcomes from the Surveillance HeartCare Outcomes Registry. J Heart Lung Transplant. 2024;43(9):1409-1421.
CareDx data on file.
Teuteberg JJ, Patel S, Baran D, et al. Multimodal molecular testing provides prognostic value for heart transplant recipients. J Heart Lung Transplant. 2025;45:388-400.
CareDx is committed to providing scientifically supported educational content for transplant recipients and caregivers. All content is for educational purposes only and is not intended to serve as medical advice or replace guidance from your healthcare provider. Always seek the advice of your transplant team with any questions you may have regarding your specific medical condition.